The Department of Pharmacology in collaboration with the University of Colorado Cancer Center has established a DNA Array Facility for the analysis of gene expression profiles in different experimental paradigms. The goal of our facility is to allow analysis of gene expression profiles in a high throughput fashion. This allows large numbers of genes to be analyzed simultaneously.

The facility analyzes expression arrays hybridized with nucleic acids from human tissue, as well as a variety of animal models, including mouse, rat and yeast. The goal of the facility is to have 40000 human genes, 20000 mouse genes and 10000 rat genes formatted for high throughput screening in the year 2000. The entire yeast genome is formatted for screening. Both cDNA and oligonucleotide arrays are being developed. Investigators in virtually all disciplines including cancer biology, development, immunology, alcohol addiction, neurobiology, and others are using the facility. Current Research The DNA Array Facility works closely with the Computational Pharmacology Center for analysis of the DNA gene expression changes that are measured in different experimental settings. Bioinformatics is essential for understanding the relevance of gene expression changes in human disease. Thus, an integrated state-of-the-art DNA Array Facility is closely aligned with the bioinformatics faculty in the department.

Source: http://www.ucdenver.edu/academics/colleges/Graduate-School/academic-programs/pharmacology/research/Pages/bioinformatics.aspx

University of Colorado Denver: Genomics and Bioinformatics

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